A total of 28,176 cases of mpox (formerly named monkeypox) have been identified through IHR mechanisms, official public sources and The European Surveillance System (TESSy) up to 10 October 2024, 14:00, from 46 countries and areas throughout the European Region. Since the last report, in the last three months, 647 cases have been reported from 21 countries and areas. Over the past 4 weeks, 211 cases of mpox have been identified from 15 countries and areas.
Case-based data were reported for 27,952 cases from 42 countries and areas to ECDC and the WHO Regional Office for Europe through TESSy, up to 10 October 2024, 10:00.
Of the 27,952 cases reported in TESSy, 27,767 were laboratory confirmed. Furthermore, among the 634 cases where sequencing results were reported, 633 were confirmed to belong to Clade II, formerly known as the West African clade. One case of Clade Ib has been reported in Sweden on August 15 in a male individual aged between 31 and 40 years, with a travel history to a country in Africa where MPXV clade I is circulating. Amongst all mpox cases reported, the earliest known case has a specimen date of 07 March 2022 and was identified through retrospective testing of a residual sample. The earliest date of symptom onset was reported as 17 April 2022.
The majority of cases were male (27,412/27,875 - 98%) with the most affected age group being 31–40 years-old (11,015/27,911 - 39%). Of the 5,302 male cases with known sexual behaviour, 97% were reported as men who have sex with men. Among cases with known HIV status, 38% (4,449/11,791) were HIV-positive. The majority of cases presented with a rash (16,326/17,643 - 93%). Systemic symptoms such as fever, fatigue, muscle pain, chills, or headache were present in 69% of cases (12,160/17,643). There were 912 cases hospitalised (7%), of which 307 cases required clinical care. Nine cases were admitted to ICU, and 9 cases were reported to have died.
An overview of the global situation can be found here: https://worldhealthorg.shinyapps.io/mpx_global/.
This report provides an overview of the total number of cases of mpox (formerly named monkeypox) identified by ECDC and the WHO Regional Office for Europe through IHR mechanisms and official public sources and case-based data through The European Surveillance System (TESSy) up to 10 October 2024.
The first summary table and maps (first two tabs) describe the number of cases identified through the different platforms. The following figures and tables describe national case-based data for surveillance of mpox reported in TESSy from all the countries and areas of the WHO European Region, including the 27 countries of the European Union (EU) and the additional three countries of the European Economic Area (EEA).
Case Report Form Data are submitted through the case-based record type mpox (MPX) to The European Surveillance System (TESSy) database hosted at ECDC.
As of 22 December 2022
Cases of mpox should be reported to TESSy if they meet any of the WHO, ECDC or national case definitions.
AND One or more of the following:
OR
AND for which the following common causes of acute rash or skin lesions do not fully explain the clinical picture:
N.B. It is not necessary to obtain negative laboratory results for listed common causes of rash illness in order to classify a case as suspected. Further, if suspicion of mpox or MPXV infection is high due to either history and/or clinical presentation or possible exposure to a case, the identification of an alternate pathogen which causes rash illness should not preclude testing for MPXV, as co-infections have been identified.
The previous WHO and ECDC case definitions can be found in the Annex.
1.PCR on a blood specimen may be unreliable and should also not be used alone as a first line diagnostic test. If blood PCR is negative and was the only test done, this is not sufficient to discard a case that otherwise meets the definition of a suspected for probable case. This applies regardless of whether the blood PCR was for OPXV or MPXV specific.
2.The person has been exposed to a probable or confirmed monkeypox case.
3.Serology can be used for retrospective case classification for a probable case in specific circumstances such as when diagnostic testing through PCR of skin lesion specimens has not been possible, or in the context of research with standardized data collection. The primary diagnostic test for monkeypox diagnosis is PCR of skin lesion material or other specimen such as an oral or nasopharygeal swab as appropriate. Serology should not be used as a first line diagnostic test.
Summary of number of cases of mpox identified through IHR mechanisms and official public sources and reported to TESSy, European Region, 2022–2024
Countries and areas reporting new cases in the past 4 ISO weeks are highlighted in blue
Overall number of cases of mpox, per date of notification, European Region, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Overall number of cases of mpox, per date of notification, EU/EEA countries, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Overall number of cases of mpox, per date of symptom onset, European Region, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Overall number of cases of mpox, per date of symptom onset, EU/EEA countries, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Number of cases of mpox, per ISO week and per country of notification, European Region, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Number of cases of mpox, per ISO week and per country/area of notification, EU/EEA countries, TESSy, 2022–2024
Date of notification is defined as the date when the case report is notified for the first time to the place of notification, date of diagnosis is defined as the first date of clinical or laboratory diagnosis, and date of onset as the date of onset of any symptoms.
Number of cases of mpox, per ISO week and per country/area of notification, European Region, TESSy, 2022–2024
*Week of symptom onset or earliest of week of diagnosis or notification if missing
Summary of number of probable and confirmed cases of mpox, and deaths, by reporting country/area, European Region, TESSy, 2022–2024
Summary of number of probable and confirmed cases of mpox, and deaths, by reporting country/area, EU/EEA countries, TESSy, 2022–2024
Age and gender distribution of cases of mpox, European Region, TESSy, 2022–2024
Gender from 18 cases is reported as Other and these cases are not depicted on this graph. Information on gender is missing for 59 cases and information on age is missing for 41 cases.
Data on gender is collected as Female, Male, Other (e.g., transgender man, transgender woman and collected as free text), or Unknown.
Age and gender distribution of cases of mpox, EU/EEA countries, TESSy, 2022–2024
Gender from 14 cases is reported as Other and these cases are not depicted on this graph. Information on gender is missing for 26 cases and information on age is missing for 29 cases.
Data on gender is collected as Female, Male, Other (e.g., transgender man, transgender woman and collected as free text), or Unknown.
Distribution of symptoms among those reporting at least one type of symptom (N=17643), European Region, TESSy, 2022–2024
The median time between symptom onset and diagnosis was 7 days.
Distribution of rash and systemic symptoms among those reporting at least one type of symptom (N=17643), European Region, TESSy, 2022–2024
*Fever, fatigue, muscle pain, chills, headache
Detection of asymptomatic cases is dependent on testing guidelines which currently do not recommend testing of asymptomatic persons
Distribution of symptoms among those reporting at least one type of symptom (N=17031), EU/EEA countries, TESSy, 2022–2024
The median time between symptom onset and diagnosis was 6 days.
Distribution of rash and systemic symptoms among those reporting at least one type of symptom (N=17031), EU/EEA countries, TESSy, 2022–2024
*Fever, fatigue, muscle pain, chills, headache
Detection of asymptomatic cases is dependent on testing guidelines which currently do not recommend testing of asymptomatic persons
Summary of outcome and HIV status of cases, European Region, TESSy, 2022–2024
*Includes cases hospitalized for isolation or treatment (199 cases were hospitalized for isolation purposes,307 required clinical care and 406 were hospitalized for unknown reasons).
Summary of outcome and HIV status of cases, EU/EEA countries, TESSy, 2022–2024
*Includes cases hospitalized for isolation or treatment (189 cases were hospitalized for isolation purposes,294 required clinical care and 405 were hospitalized for unknown reasons).
Summary of reported sexual behaviours among male cases of mpox, European Region, TESSy, 2022–2024
Sexual behaviours in TESSy is defined according to the following non-mutually exclusive categories:
Sexual behaviour is not necessarily representative of the gender of the person the case had sex with in the past 21 days nor does it imply sexual contact and sexual transmission.
We summarize here the sexual behaviour that male cases identified with.
Summary of reported sexual behaviours among male cases of mpox, EU/EEA countries, TESSy, 2022–2024
Sexual behaviour in TESSy is defined according to the following non-mutually exclusive categories:
Sexual behaviour is not necessarily representative of the gender of the person the case had sex with in the past 21 days nor does it imply sexual contact and sexual transmission.
We summarize here the sexual behaviour that male cases identified with.
Summary of specimen types with positive test result used for diagnosis of mpox, European Region, TESSy, 2022–2024
Summary of specimen types with positive test result used for diagnosis of mpox, EU/EEA countries, TESSy, 2022–2024
Phylogenetics of mpox virus
Phylogeny of human monkeypox virus was performed using Nextstrain. Briefly, genome sequences were extracted from Nextstrain repository comprising the curated NCBI GenBank sequences and metadata that were quality assessed using Nextclade1. The sequences were filtered for the Nextstrain curated exclusions, minimum length of 10000 bp, collected from 2017 and subsampling of 40 samples per country during the same sampling month and year. The phylogenetic analysis was performed using Nextalign (masking specific sites), IQTREE to construct the tree and TreeTime to refine the tree and visualized using Microreact2.
There are two genetically distinct clades described for monkeypox virus: Clade I and Clade II with sub-clades IIa and IIb3,4. The current outbreak falls within Clade IIb and following the nomenclature used in Nextstrain, a majority of the 2022 sequences belong to lineage B.14,5. A few sequences do not cluster with the outbreak sequences but fall into lineages A.2 and A.36-8.
Aksamentov I, Roemer C, Hodcroft EB, & Neher RA. (2021). Nextclade: clade assignment, mutation calling and quality control for viral genomes. Journal of Open Source Software, 6(67), 3773, https://doi.org/10.21105/joss.03773
Argimón S, et al. Microreact: visualizing and sharing data for genomic epidemiology and phylogeography. Microbial Genomics. 2016;2(11). Available at: https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000093
World Health Organization. Monkeypox: experts give virus variants new names, 12 August 2022. Available at: https://www.who.int/news/item/12-08-2022-monkeypox--experts-give-virus-variants-new-names
Happi C, et al. Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus. Virological. Available at: https://virological.org/t/urgent-need-for-a-non-discriminatory-and-non-stigmatizing-nomenclature-for-monkeypox-virus/853
Nextstrain Genomic epidemiology of monkeypox virus. Available at: https://nextstrain.org/monkeypox/hmpxv1
Yadav PD, Reghukumar A, Rima R, Sahay RR, et al. First two cases of Monkeypox virus infection in a traveller returned from UAE to India, July 2022, Journal of Infection, 2022. Available at: https://doi.org/10.1016/j.jinf.2022.08.007
The UK Health Security Agency. Investigation into monkeypox
outbreak in England: technical briefing 8, 23 September 2022. Available
at:
https://www.gov.uk/government/publications/monkeypox-outbreak-technical-briefings/investigation-into-monkeypox-outbreak-in-england-technical-briefing-8
Gigante CM, et al. Multiple lineages of Monkeypox virus detected in the United States, 2021-2022. Science. 2022;378(6619). Available at: https://doi.org/10.1126/science.add4153
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Suggested citation: European Centre for Disease Prevention and Control/WHO Regional Office for Europe. Mpox, Joint Epidemiological overview, 16 October 2024.
Tables and figures should be referenced: European Centre for Disease Prevention and Control/WHO Regional Office for Europe. Mpox, Joint Epidemiological overview, 16 October 2024.
© World Health Organization 2024.
© European Centre for Disease Prevention and Control 2024.
Some rights reserved. This work is available under the Creative Commons Attribution- 4.0 International (CC BY-4.0 ; Creative Commons — Attribution 4.0 International — CC BY 4.0. In any use of this work, there should be no suggestion that WHO or ECDC endorse any specific organization, products or services. The use of the ECDC or WHO logo is not permitted. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the European Centre for Disease Prevention and Control (ECDC) or by the World Health Organization (WHO). ECDC and WHO are not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition.”
We gratefully acknowledge the Nextstrain team, the authors, originating and submitting laboratories of the genetic sequences and metadata (NCBI Genbank) for sharing their work.
WHO and ECDC case definition prior to 22/12/2022
Cases of monkeypox should be reported to TESSy if they meet any of the WHO, ECDC or national case definitions.
AND One or more of the following:
OR
AND for which the following common causes of acute rash or skin lesions do not fully explain the clinical picture:
N.B. It is not necessary to obtain negative laboratory results for listed common causes of rash illness in order to classify a case as suspected. Further, if suspicion of monkeypox infection is high due to either history and/or clinical presentation or possible exposure to a case, the identification of an alternate pathogen which causes rash illness should not preclude testing for MPXV, as coinfections have been identified.
Both the previous WHO and ECDC case definitions can be found in the Annex.
1.PCR on a blood specimen may be unreliable and should also not be used alone as a first line diagnostic test. If blood PCR is negative and was the only test done, this is not sufficient to discard a case that otherwise meets the definition of a suspected for probable case. This applies regardless of whether the blood PCR was for OPXV or MPXV specific.
2.The person has been exposed to a probable or confirmed monkeypox case. Please see below definition of a contact.
3.Serology can be used for retrospective case classification for a probable case in specific circumstances such as when diagnostic testing through PCR of skin lesion specimens has not been possible, or in the context of research with standardized data collection. The primary diagnostic test for monkeypox diagnosis is PCR of skin lesion material or other specimen such as an oral or nasopharyngeal swab as appropriate. Serology should not be used as a first line diagnostic test.
ECDC case definition for monkeypox prior to 08/09/2022 :
AND one of the following:
OR
Since EU/EEA countries are just starting to identify cases and if testing capacity is sufficient, the above more sensitive case definition can be used. In countries with limited testing capacity for orthopoxviruses, the following description can be added to characterize the rash: ‘unexplained localized or generalized maculopapular or vesiculopustular rash potentially with umbilication or scabbing’.
Fever (usually higher >38.5°C), headache, back ache, fatigue, lymphadenopathy (localized or generalized).
WHO case definition for monkeypox prior to 25/08/2022 :
AND One or more of the following:
AND one or more of the following signs or symptoms:
AND for which the following common causes of acute rash or skin lesions do not fully explain the clinical picture:
N.B. It is not necessary to obtain negative laboratory results for listed common causes of rash illness in order to classify a case as suspected. Further, if suspicion of monkeypox infection is high due to either history and/or clinical presentation or possible exposure to a case, the identification of an alternate pathogen which causes rash illness should not preclude testing for MPXV, as coinfections have been identified.
PCR on a blood specimen may be unreliable and should also not be used alone as a first line diagnostic test. If blood PCR is negative and was the only test done, this is not sufficient to discard a case that otherwise meets the definition of a suspected for probable case. This applies regardless of whether the blood PCR was for OPXV or MPXV specific.
Evidence is currently lacking as to the duration of exposure necessary for infection by the respiratory route, including how it relates to the severity of the index case’s disease. Characterization of this parameter is one of the goals of the case investigation form described below
Serology can be used for retrospective case classification for a probable case in specific circumstances such as when diagnostic testing through PCR of skin lesion specimens has not been possible, or in the context of research with standardized data collection. The primary diagnostic test for monkeypox diagnosis is PCR of skin lesion material or other specimen such as an oral or nasopharyngeal swab as appropriate. Serology should not be used as a first line diagnostic test.